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Phosphatidylserine: Benefits for Memory and Focus, How It Works, Sources and Safety

The brain-cell nutrient you may not have heard of.

Quick answer

Phosphatidylserine (PS) is a phospholipid that forms part of every cell membrane and is especially concentrated in the brain, where it helps neurons communicate. Levels tend to decline with age. Studies, mostly in older adults, suggest PS may support memory and cognitive function, and some research has looked at its effect on the stress hormone cortisol. Food sources include fish, organ meats and white beans. The FDA allows a qualified health claim that PS may reduce the risk of cognitive dysfunction in the elderly, noting the evidence is limited. PS is generally well tolerated; high doses may cause stomach upset or trouble sleeping.

Key takeaways

Phosphatidylserine is one of the few brain nutrients with a qualified health claim allowed by the FDA. Here is what it does.

How phosphatidylserine works

Membrane fluidity

PS keeps neuron membranes flexible so receptors and ion channels can work properly.

Cell signalling

It helps activate enzymes involved in signalling and supports the release of neurotransmitters such as acetylcholine.

Stress response

Some studies suggest PS may help moderate the cortisol response to physical and mental stress.

PS at a glance

TopicDetail
TypePhospholipid
Highest concentrationBrain
Food sourcesMackerel, herring, tuna, organ meats, white beans
Main research areasMemory, cognition in older adults, stress
Common side effectsStomach upset, insomnia at high doses

Phosphatidylserine in Brain Savior

Brain Savior combines phosphatidylserine with bacopa, ginkgo, Siberian ginseng and alpha lipoic acid in a caffeine-free formula designed to support concentration, memory and mental energy.

Safety: PS may have additive effects with blood thinners and with anticholinergic or cholinergic medicines. Talk to your doctor before use if you take medication or are pregnant or nursing.

Sources

  1. Glade M.J. & Smith K. – "Phosphatidylserine and the human brain," Nutrition, 2015.
  2. U.S. FDA – "Letter regarding phosphatidylserine and cognitive dysfunction and dementia (qualified health claim)," 2003.
  3. Kim H.Y. et al. – "Phosphatidylserine in the brain: metabolism and function," Progress in Lipid Research, 2014.

Common questions

What does phosphatidylserine do?

It supports brain-cell membranes and communication between neurons.

Which foods contain phosphatidylserine?

Fish such as mackerel and herring, organ meats and white beans.

Is phosphatidylserine safe?

It is generally well tolerated; check with a doctor if you take medication.

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